Certificate under SEBI (Depositories and Participants) Regulations, 2018

Ref: Syn/CS/SE/ DPR-74(5)/2026-27/Oct/02 Syngene International Limited Biocon SEZ, Biocon Park, Plot No. 2 & 3, Bommasandra Industrial Area, IV Phase, Jigani Link Road, Bengaluru 560 099, Karnataka, India T +91 80 6891 9191 CIN: L85110KA1993PLC014937 www.syngeneintl.com October 08, 2026 To, To, The Manager, The Manager, BSE Limited National Stock Exchange of India Limited Corporate Relationship Department Corporate Communication Department Dalal Street, Mumbai – 400 001 Bandra (EAST), Mumbai – 400 051 Scrip Code: 539268 Scrip Symbol: SYNGENE Dear Sir/Madam, Subject: Certificate under Regulation 74(5) of SEBI (Depositories and Participants) Regulations, 2018. This is to certify that the details of securities dematerialized during the quarter ended September 30, 2026, as required under Regulation 74(5) of SEBI (Depositories and Participants) Regulations, 2018 have been furnished to all stock exchanges where the shares of Syngene International Limited are listed. The letter from the RTA i.e., M/s. KFin Technologies Limited dated October 06, 2026, confirming the above is enclosed for your reference. Thanking you, Yours faithfully, For SYNGENE INTERNATIONAL LIMITED Chethan Yogesh Company Secretary & Compliance Officer Enclosed: Certificate from the RTA under regulation 74(5) KFIN2026-27/74(5)Q2/Certificate Date: 06.10.2026 THE COMPANY SECRETARY SYNGENE INTERNATIONAL LIMITED SEZ UNIT BIOCON SPECIAL ECONOMIC ZONE BOMMASANDRA –JIGANI LINK ROAD BANGALORE 560099 Subject:ConfirmationCertificateunderRegulation74(5)ofSecuritiesandExchangeBoardofIndia(Depositoriesand Participants) Regulations, 2018 (‘Regulations’) in respect of Equity Shares of the Company DearSirs/Madam, With reference to the above captioned Regulations, we hereby confirm that during the period 1st July, 2026 to 30th September, 2026 we have within 15 days from date of receipt of the certificates from the depository participants for dematerialization; (cid:120) confirmed(approved/rejected)dematrequests; (cid:120) confirmed to the depositories that securities comprised in the said certificates have been listed on the stock exchanges where the earlier issued securities are listed; (cid:120) immediatelymutilatedandcancelledthesaidsecuritycertificatesafterdueverificationand (cid:120) Nameofthedepositorieshavebeensubstitutedinregisterofmembersastheregisteredowner,incaseofdemat requests which are approved. Further,wehavebeencertifyingthesametothedepositoriesandStockExchangesinaccordancewithRegulations. We request you to kindly take note of the above. Thankingyou Yoursfaithfully, ForKFINTECHNOLOGIESLIMITED DSureshBabu Sr. Manager