Certificate under SEBI (Depositories and Participants) Regulations, 2018

Ref: Syn/CS/SE/DPR-74(5)/2026-27/Jul/10 Syngene International Limited Biocon SEZ, Biocon Park, Plot No. 2 & 3, Bommasandra Industrial Area, IV Phase, Jigani Link Road, Bengaluru 560 099, Karnataka, India T +91 80 6891 9191 CIN: L85110KA1993PLC014937 www.syngeneintl.com July 10, 2026 To, To, The Manager, The Manager, BSE Limited National Stock Exchange of India Limited Corporate Relationship Department Corporate Communication Department Dalal Street, Mumbai – 400 001 Bandra (EAST), Mumbai – 400 051 Scrip Code: 539268 Scrip Symbol: SYNGENE Dear Sir/Madam, Subject: Certificate under Regulation 74(5) of SEBI (Depositories and Participants) Regulations, 2018. This is to certify that the details of securities dematerialized during the quarter ended June 30, 2026, as required under Regulation 74(5) of SEBI (Depositories and Participants) Regulations, 2018 have been furnished to all stock exchanges where the shares of Syngene International Limited are listed. The letter from the RTA i.e., M/s. KFin Technologies Limited dated July 03, 2026, confirming the above is enclosed for your reference. Thanking you, Yours faithfully, For SYNGENE INTERNATIONAL LIMITED Chethan Yogesh Company Secretary & Compliance Officer Enclosed: Certificate from the RTA under regulation 74(5) KFIN 2026-27/74(5) Q1/Certificate Date: 03.07.2026 THE COMPANY SECRETARY SYNGENE INTERNATIONAL LIMITED SEZ UNIT BIOCON SPECIAL ECONOMIC ZONE BOMMASANDRA – JIGANI LINK ROAD BANGALORE 560099 Subject: Confirmation Certificate under Regulation 74(5) of Securities and Exchange Board of India (Depositories and Participants) Regulations, 2018 (‘Regulations’) in respect of Equity Shares of the Company Dear Sirs/Madam, With reference to the above captioned Regulations, we hereby confirm that during the period 1st April, 2026 to 30th June, 2026 we have within 15 days from date of receipt of the certificates from the depository participants for dematerialization; • confirmed (approved/rejected) demat requests; • confirmed to the depositories that securities comprised in the said certificates have been listed on the stock exchanges where the earlier issued securities are listed; • immediately mutilated and cancelled the said security certificates after due verification and • Name of the depositories have been substituted in register of members as the registered owner, in case of demat requests which are approved. Further, we have been certifying the same to the depositories and Stock Exchanges in accordance with Regulations. We request you to kindly take note of the above. Thanking you Yours faithfully, For KFIN TECHNOLOGIES LIMITED D Suresh Babu Sr. Manager